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Catalog# Product Description |
ICP6010 The Stat1 transcription factor is activated in response to a large number of ligands and is essential for responsiveness to IFN-α and IFN-γ. These antibodies were raised based on the human Stat1 sequence (690-720 aa) and tested in western blotting of human and mouse cell lysate and mouse tissue (spleen) extract to detect Stat1. |
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Western blot analysis of the extract from mouse spleen ICP0610.
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Species
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Rabbit
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Formulation
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250 μg/mL in PBS, pH7 with 50% glycerol
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Immunogen
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Human Stat1 peptide KLH conjugates
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Purification
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Affinity purified chromatography
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Specificity
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The antibody recognizes Stat1 from human and mouse.
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Applications
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ELISA; WB; IHC
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Scientific Description
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STAT1 and STAT2 were the first two STAT (signal transducers and activators of transcription) proteins discovered. They are involved in interferon-alpha (IFN-alpha) and IFN-gamma signal transduction. Other STAT proteins that have been identified are STAT3, 4, 5a, 5b, and 6.[1] Specific functions of the STAT proteins are poorly understood. They are thought to be involved in a variety of systems including antiviral responses and cell transformation. [2]
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Storage & Stability
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Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is one year from date of shipping if stored properly.
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Product Specific References |
1. Cell, 1996. 84(3): 331-334. doi:10.1016/S0092-8674(00)81277-5 2. Eur. J. Biochem. 1997. 248(3): 615-633, doi:10.1111/j.1432-1033.1997.00615.x |
