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Catalog# Product Description |
ICP7110 These antibodies were developed based on human p53 sequences (25-40 aa). It was tested to detect human p53 in human cell and tissue. |
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Western blot analysis of p53 in HeLa cell lysates with p53 antibody (ICP7110) A: 15 μg/mL crude protein B: 45 μg/mL crude protein
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Species
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Rabbit
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Formulation
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250 μg/mL in PBS, pH 7, with 50 % glycerol
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Immunogen
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Human phosphor p53 peptide (15-40 aa) KLH conjugates
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Purification
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Peptide-affinity chromatography
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Specificity
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The antibody recognizes human p53 in cell and tissue.
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Species Tested
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Mouse and human
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Applications
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ELISA (1:2500); WB (1:2500)
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Scientific Description
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P53 (tumour protein 53 or TP53) regulates the cell cycle by acting as a transcription factor. It suppresses tumours and hence it is often described as "the guardian of the genome", "the guardian angel gene", or the "master watchman". This refers to its role in conserving stability by preventing genome mutation. P53 refers to its molecular mass (53 kDa) on SDS-PAGE.
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Storage & Stability
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Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is one year from date of shipping if stored properly.
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Product Specific References
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1. Strachan T. et al. Human Molecular Genetics 2. Ch. 18, 1999 Cancer Genetics.
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