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Catalog # Product Description |
CN0820 The affinity purified rabbit polyclonal anti-HDAC 6 antibody is developed using the C-terminal peptide of human histone deacetylase 6. It could be used for the detection and isolation of HDAC 6. |
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Species
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Rabbit
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Formulation
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250 μg/mL in TBS, 50% glycerol, 0.01 NaN3
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Immunogen
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Human HDAC 6 (protein code: NP_006035) C-terminal peptide-KLH conjugate
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Purification
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The antibody is purified with antigen-specific immunoaffinity chromatography.
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Specificity
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The antibody recognizes human HDAC 6. It may cross react with HDAC from other species.
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Applications
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ELISA (0.25 - 1.0 μg/mL); WB (0.25 - 1.0 μg/mL)
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Scientific Description
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Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from the ε-N-acetyl lysine amino acid on histones or other proteins. Its action is opposite to that of histone transferase.
HDAC proteins are found in three groups, the first two groups belong to the classical HDACs, whose activities are inhibited by trichostatin A (TSA). The third group is a family of NAD+-dependent proteins which are unaffected by TSA. Homologues to all three groups are found in yeast: reduced potassium dependency 3 (Rpd3) which corresponds to class 1, histone deacetylase 1 (hda1) to class 2 and silent information regulator 2 (Sir 2) corresponding to class 3.
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Storage & Stability
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Product is stable for several weeks at 4°C. For extended storage, store product at –20oC. Expiration date is three years from date of shipping if properly stored.
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